BDBM8903 (1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one::CHEMBL103::progesterone

SMILES [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

InChI Key InChIKey=RJKFOVLPORLFTN-LEKSSAKUSA-N

Data  38 KI  51 IC50  4 Kd  26 EC50

PDB links: 31 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8903   

TargetMineralocorticoid receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataKd:  0.390nMAssay Description:Affinity for recombinant Mineralocorticoid receptorMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50:  30nMAssay Description:Inhibition of 10e-9 M aldosterone activity in CV-1 cells expressing mineralocorticoid receptorMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50:  14nMAssay Description:Antagonistic activity was determined in Human mineralocorticoid receptor(hMR) of CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity (IC50) against human mineralocorticoid receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against human Mineralocorticoid receptorMore data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at mineralocorticoid receptor (hMR)More data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50: >14nMAssay Description:Inhibitory activity against human mineralocorticoid receptor (hMR)More data for this Ligand-Target Pair